AV Akademikerverlag ( 03.02.2016 )
€ 39,90
Cell migration in confined environments is a burning topic, since it is one of the main biological processes ruling embryogenesis, cancer metastasis or an organism immune system. Based on a previously developed cell confined migration model and the observation of micro-channels experiments, this thesis focuses of two main aspects. First, the evidence that the nucleus was capable of breaking its lamina to pass through narrow sub-nuclear constrictions led us to reconsider the way it was defined: different rheological models for the lamina and the nucleoplasm are thus used. Secondly, the confined migration model relied on an adhesion-based migration mode, while all the recent interest in cell migration through confined environments featured a compression-based migration mode in which the cell would not need to form any focal adhesions with the substrate. Hence, a new migration model is developed to describe this adhesion-free mode that mostly occurs during three-dimensional confined migration and is referred to as ’chimneying’, since it mimics the behavior of a rock climber in a chimney.
Buch Details: |
|
ISBN-13: |
978-3-639-87239-2 |
ISBN-10: |
3639872398 |
EAN: |
9783639872392 |
Buchsprache: |
English |
von (Autor): |
Solenne Deveraux |
Seitenanzahl: |
64 |
Veröffentlicht am: |
03.02.2016 |
Kategorie: |
Mechanik, Akustik |