AV Akademikerverlag ( 19.04.2019 )
€ 54,90
Osteosarcoma is the most common type of bone cancer. Although stage I osteosarcoma has a promising prognosis, stage III osteosarcoma with lung metastases with only about 30% survival rate is worrying. Expression of EGFR and its downstream proteins has been regularly observed in osteosarcoma. In this book, the main focus is on two major aims: 1.Analysis of the role of EGFR signaling during bone tumor formation by breeding H2-c-fosLTR transgenic mice, that develop OS with 100% penetrance, to mice that harbor either reduced (Egfrwa2/wa2) or elevated (Col1-AREG) EGFR signaling; 2.Analysis of the effect of EGFR inhibition on proliferation, viability and apoptosis as well as on EGFR downstream signaling proteins in c fos transgenic osteosarcoma cells.
Buch Details: |
|
ISBN-13: |
978-620-2-21347-9 |
ISBN-10: |
6202213477 |
EAN: |
9786202213479 |
Buchsprache: |
English |
Herausgegeben von: |
Markus Linder |
Seitenanzahl: |
96 |
Veröffentlicht am: |
19.04.2019 |
Kategorie: |
Biologie |